2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (1901):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-W048504
    1-[3’-O-[(4,4’-Dimethoxytriphenyl)methyl]-a-L-threofuranosyl]-N4-benzoylcytosine
    1-[3’-O-[(4,4’-Dimethoxytriphenyl)methyl]-a-L-threofuranosyl]-N4-benzoylcytosine is a cytidine analog. Cytidine analogs have a mechanism of inhibiting DNA methyltransferases (such as Zebularine, HY-13420), and have potential anti-metabolic and anti-tumor activities.
    1-[3’-O-[(4,4’-Dimethoxytriphenyl)methyl]-a-L-threofuranosyl]-N4-benzoylcytosine
  • HY-152993
    2′-Deoxy-N-(2-furanylmethyl)guanosine
    2′-Deoxy-N-(2-furanylmethyl)guanosine is a guanosine analog. Some guanosine analogs have immunostimulatory activity. In some animal models, they also induce type I interferons, producing antiviral effects. Studies have shown that the functional activity of guanosine analogs is dependent on the activation of Toll-like receptor 7 (TLR7).
    2′-Deoxy-N-(2-furanylmethyl)guanosine
  • HY-154060
    N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)adenosine
    N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N6-Benzoyl-5'-O-(4,4'-dimethoxytrityl)-3'-O-(2-methoxyethyl)adenosine
  • HY-B1449S2
    Uridine-13C-1
    Uridine-13C-1 is the 13C labeled Uridine.
    Uridine-<sup>13</sup>C-1
  • HY-152338
    7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
    7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    7-Propargyl-7,8-dihydro-8-oxo-9-(β-D-xylofuranosyl)guanine
  • HY-152390
    2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine
    2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-Fluoro-2’-deoxy-N6-methylarabinoadenosine
  • HY-160704
    CMX-521
    CMX-521, a nucleoside analog, is a potent inhibitor for RNA-dependant RNA polymerase (RdRp) of norovirus. CMX-521 suppresses murine norovirus (MNV) and human norovirus.
    CMX-521
  • HY-B0158S4
    Cytidine-d
    Cytidine-d is the deuterium labeled Cytidine. Cytidine is a pyrimidine nucleoside and acts as a component of RNA. Cytidine is a precursor of uridine. Cytidine controls neuronal-glial glutamate cycling, affecting cerebral phospholipid metabolism, catechol
    Cytidine-d
  • HY-B0078S
    Dacarbazine-d6
    		Inhibitor
    Dacarbazine-d6 is the deuterium labeled Dacarbazine. Dacarbazine(DTIC-Dome; DTIC) is an antineoplastic agent. It has significant activity against melanomas.
    Dacarbazine-d<sub>6</sub>
  • HY-152521
    2-Amino-6-meThythio-9-(β-D-ribofuranosyl)-9H-purine
    2-Amino-6-meThythio-9-(β-D-ribofuranosyl)-9H-purine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2-Amino-6-meThythio-9-(β-D-ribofuranosyl)-9H-purine
  • HY-152429
    3’-Beta-C-ethynyl-5-trifluoromethyluridine
    3’-Beta-C-ethynyl-5-trifluoromethyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 3’-Beta-C-ethynyl-5-trifluoromethyluridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-Beta-C-ethynyl-5-trifluoromethyluridine
  • HY-147969
    Antiangiogenic agent 2
    		Inhibitor
    Antiangiogenic agent 2 (compound 3b) is a potent thymidine phosphorylase inhibitor, with an IC50 of 39.71 μM. Antiangiogenic agent 2 shows anti-angiogenic activity.
    Antiangiogenic agent 2
  • HY-154563
    2’,3’,5’-Tri-O-acetyl-5,N3-dimethyluridine
    2’,3’,5’-Tri-O-acetyl-5,N3-dimethyluridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis.
    2’,3’,5’-Tri-O-acetyl-5,N3-dimethyluridine
  • HY-A0005R
    Clofarabine (Standard)
    		Inhibitor
    Clofarabine (Standard) is the analytical standard of Clofarabine. This product is intended for research and analytical applications. Clofarabine, a nucleoside analogue for research of cancer, is a potent inhibitor of ribonucleotide reductase (IC50=65 nM) by binding to the allosteric site on the regulatory subunit.
    Clofarabine (Standard)
  • HY-154399
    5-Aza-3’-deoxycytidine
    5-Aza-3’-deoxycytidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5-Aza-3’-deoxycytidine
  • HY-152466
    2’-O-Methyl-N1-methyladenosine
    2’-O-Methyl-N1-methyladenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    2’-O-Methyl-N1-methyladenosine
  • HY-152343
    1-(β-D-Xylofuranosyl)-2-thiouracil
    1-(β-D-Xylofuranosyl)-2-thiouracil is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    1-(β-D-Xylofuranosyl)-2-thiouracil
  • HY-152488
    3’-β-C-Ethynyl-5-methyl uridine
    3’-β-C-Ethynyl-5-methyl uridine is a thymidine analog. Analogs of this series have insertional activity towards replicated DNA. They can be used to label cells and track DNA synthesis. 3’-β-C-Ethynyl-5-methyl uridine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    3’-β-C-Ethynyl-5-methyl uridine
  • HY-154140
    3’-beta-C-Methyl-N6-(p-methoxybenzyl)adenosine
    3’-beta-C-Methyl-N6-(p-methoxybenzyl)adenosine is a n adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    3’-beta-C-Methyl-N6-(p-methoxybenzyl)adenosine
  • HY-152878
    Arabinosylisocytosine
    2-Amino-1-β-D-arabinofuranosyl-4(1H)-pyrimidinone is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    Arabinosylisocytosine